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Nanostructured hydrogels for three-dimensional cell culture through self-assembly of fluorenylmethoxycarbonyl-dipeptides

Jayawarna, V and Ali, M and Jowitt, T A and Miller, A E and Saiani, A and Gough, J E and Ulijn, R V (2006) Nanostructured hydrogels for three-dimensional cell culture through self-assembly of fluorenylmethoxycarbonyl-dipeptides. Advanced Materials, 18 (5). pp. 611-614. ISSN 0935-9648

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Abstract

A number of short peptide amphiphiles consisting of dipeptides linked to fluorenylmethoxycarbonyl spontaneously form fibrous hydrogels under physiological conditions (see figure). The structural and physical properties of these gels are dictated by the amino acid sequence of the peptide building blocks, and the gels support the three-dimensional cell culture of chondrocytes.