Reagan, Michaela R and Seib, F Philipp and McMillin, Douglas W and Sage, Elizabeth K and Mitsiades, Constantine S and Janes, Sam M and Ghobrial, Irene M and Kaplan, David L (2012) Stem cell implants for cancer therapy : TRAIL-expressing mesenchymal stem cells target cancer cells in situ. Journal of breast cancer, 15 (3). pp. 273-282. ISSN 2092-9900
Full text not available in this repository. (Request a copy from the Strathclyde author)Abstract
Tumor-specific delivery of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), an apoptosis-inducing peptide, at effective doses remains challenging. Herein we demonstrate the utility of a scaffold-based delivery system for sustained therapeutic cell release that capitalizes on the tumor-homing properties of mesenchymal stem cells (MSCs) and their ability to express genetically-introduced therapeutic genes.
| Item type: | Article |
|---|---|
| ID code: | 42105 |
| Keywords: | breast neoplasms, mesenchymal stem cells, tissue engineering, tissue therapy, TNF-related apoptosis-inducing ligand, Pharmacy and materia medica |
| Subjects: | Medicine > Pharmacy and materia medica |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
| Related URLs: | |
| Depositing user: | Pure Administrator |
| Date Deposited: | 16 Nov 2012 11:56 |
| Last modified: | 16 Nov 2012 11:56 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/42105 |
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