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The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including by Strathclyde researchers from the Department of Computer & Information Sciences involved in researching exciting new applications for mobile and smartphone technology. But the transformative application of mobile technologies is also the focus of research within disciplines as diverse as Electronic & Electrical Engineering, Marketing, Human Resource Management and Biomedical Enginering, among others.

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Stem cell implants for cancer therapy : TRAIL-expressing mesenchymal stem cells target cancer cells in situ

Reagan, Michaela R and Seib, F Philipp and McMillin, Douglas W and Sage, Elizabeth K and Mitsiades, Constantine S and Janes, Sam M and Ghobrial, Irene M and Kaplan, David L (2012) Stem cell implants for cancer therapy : TRAIL-expressing mesenchymal stem cells target cancer cells in situ. Journal of breast cancer, 15 (3). pp. 273-282.

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Abstract

Tumor-specific delivery of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), an apoptosis-inducing peptide, at effective doses remains challenging. Herein we demonstrate the utility of a scaffold-based delivery system for sustained therapeutic cell release that capitalizes on the tumor-homing properties of mesenchymal stem cells (MSCs) and their ability to express genetically-introduced therapeutic genes.