Reagan, Michaela R and Seib, F Philipp and McMillin, Douglas W and Sage, Elizabeth K and Mitsiades, Constantine S and Janes, Sam M and Ghobrial, Irene M and Kaplan, David L (2012) Stem cell implants for cancer therapy : TRAIL-expressing mesenchymal stem cells target cancer cells in situ. Journal of breast cancer, 15 (3). pp. 273-282. ISSN 2092-9900Full text not available in this repository. (Request a copy from the Strathclyde author)
Tumor-specific delivery of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), an apoptosis-inducing peptide, at effective doses remains challenging. Herein we demonstrate the utility of a scaffold-based delivery system for sustained therapeutic cell release that capitalizes on the tumor-homing properties of mesenchymal stem cells (MSCs) and their ability to express genetically-introduced therapeutic genes.
|Keywords:||breast neoplasms, mesenchymal stem cells, tissue engineering, tissue therapy, TNF-related apoptosis-inducing ligand, Pharmacy and materia medica|
|Subjects:||Medicine > Pharmacy and materia medica|
|Department:||Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences|
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|Depositing user:||Pure Administrator|
|Date Deposited:||16 Nov 2012 11:56|
|Last modified:||12 Jun 2013 14:34|
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