Seib, Friedrich Philipp and Pritchard, Eleanor M. and Kaplan, David L. (2013) Self-assembling doxorubicin silk hydrogels for the focal treatment of primary breast cancer. Advanced Functional Materials, 23 (1). 58–65. ISSN 1616-301XFull text not available in this repository. (Request a copy from the Strathclyde author)
Standard care for early stage breast cancer includes tumor resection and local radiotherapy to achieve long-term remission. Systemic chemotherapy provides only low locoregional control of the disease; to address this, self- assembling silk hydrogels that can retain and then deliver doxorubicin locally are described. Self-assembling silk hydrogels show no swelling, are readily loaded with doxorubicin under aqueous conditions, and release drug over 4 weeks in amounts that can be fine-tuned by varying the silk content. Fol- lowing successful in vitro studies, locally injected silk hydrogels loaded with doxorubicin show excellent antitumor response in mice, outperforming the equivalent amount of doxorubicin delivered intravenously. In addition to reducing primary tumor growth, doxorubicin-loaded silk hydrogels reduce metastatic spread and are well tolerated in vivo. Thus, silk hydrogels are well suited for the local delivery of chemotherapy and provide a promising approach to improve locoregional control of breast cancer.
|Keywords:||silk hydrogels, cancer, adriamycin, drug delivery, Pharmacy and materia medica|
|Subjects:||Medicine > Pharmacy and materia medica|
|Department:||Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences|
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|Depositing user:||Pure Administrator|
|Date Deposited:||16 Nov 2012 11:53|
|Last modified:||12 Jun 2013 14:34|
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