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Self-assembling doxorubicin silk hydrogels for the focal treatment of primary breast cancer

Seib, Friedrich Philipp and Pritchard, Eleanor M. and Kaplan, David L. (2013) Self-assembling doxorubicin silk hydrogels for the focal treatment of primary breast cancer. Advanced Functional Materials, 23 (1). 58–65. ISSN 1616-301X

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Abstract

Standard care for early stage breast cancer includes tumor resection and local radiotherapy to achieve long-term remission. Systemic chemotherapy provides only low locoregional control of the disease; to address this, self- assembling silk hydrogels that can retain and then deliver doxorubicin locally are described. Self-assembling silk hydrogels show no swelling, are readily loaded with doxorubicin under aqueous conditions, and release drug over 4 weeks in amounts that can be fine-tuned by varying the silk content. Fol- lowing successful in vitro studies, locally injected silk hydrogels loaded with doxorubicin show excellent antitumor response in mice, outperforming the equivalent amount of doxorubicin delivered intravenously. In addition to reducing primary tumor growth, doxorubicin-loaded silk hydrogels reduce metastatic spread and are well tolerated in vivo. Thus, silk hydrogels are well suited for the local delivery of chemotherapy and provide a promising approach to improve locoregional control of breast cancer.

Item type: Article
ID code: 42104
Keywords: silk hydrogels, cancer, adriamycin, drug delivery, Pharmacy and materia medica
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Technology and Innovation Centre > Bionanotechnology
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    Depositing user: Pure Administrator
    Date Deposited: 16 Nov 2012 11:53
    Last modified: 12 Jun 2013 14:34
    URI: http://strathprints.strath.ac.uk/id/eprint/42104

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