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The vitreous humor as a barrier to nanoparticle distribution

Mains, Jenifer and Wilson, Clive (2012) The vitreous humor as a barrier to nanoparticle distribution. Journal of Ocular Pharmacology and Therapeutics. ISSN 1080-7683

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Abstract

The vitreous humor represents a significant barrier to the penetration of nanoparticulate-based ocular drug delivery systems. The gel structure and biochemical components of the vitreous will impact on the rate of nanoparticle movement through the tissue to reach the retinal tissue. As well as structure of the vitreous, flow systems operating within the vitreous, age-related structural changes, and the presence of inflammation will also have a potential effect on movement. To effectively target the posterior retina, the physical properties of the nanoparticle formulation are a key element in the design of a system that will penetrate through the vitreous barrier.