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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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Effect of choice of outcome measure on studies of the etiology of obesity in children

Basterfield, Laura and Pearce, Mark S and Adamson, Ashley J and Reilly, Jessica K and Parkinson, Kathryn N and Reilly, John J and , the Gateshead Millennium Study Core Team (2012) Effect of choice of outcome measure on studies of the etiology of obesity in children. Annals of Epidemiology, 22 (12). pp. 888-891.

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Abstract

Epidemiologic studies of the etiology of childhood obesity often use proxies for adiposity as outcomes. This study aimed to compare the ability of a range of proxy measures to detect associations with sedentary behavior. Longitudinal study of children in the Gateshead Millennium Study who were 7 years at baseline and 9 years at follow-up. Associations between 2-year changes in objectively measured sedentary behavior and changes in proxies for adiposity (waist circumference, waist Z score, body mass index, body mass index Z score) and measurement of body composition (fat mass index from bioelectric impedance) were examined. Associations were tested with linear regression. Associations between 2-year increases in sedentary behavior and increases in adiposity were detectable by using the fat mass index as the outcome, but not the simple proxy measures of adiposity, as outcomes. Proxy measures are inferior to measures of body composition as outcomes in epidemiologic studies.