Strathprints logo
Strathprints Home | Open Access | Browse | Search | User area | Copyright | Help | Library Home | SUPrimo

Shigella sonnei genome sequencing and phylogenetic analysis indicate recent global dissemination from Europe

Holt, K. and Baker, Stephen and Weill, François-Xavier and Holmes, Edward C. and Kitchen, Andrew and Yu, Jun and Sangal, Vartul and Brown, Derek J. and Coia, John E. and Kim, Dong Wook and Choi, Seon Young and Kim, Su Hee and da Silveira, Wanderley D. and Pickard, Derek J. and Farrar, Jeremy J. and Parkhill, Julian and Dougan, Gordon and Thomson, Nicholas R. (2012) Shigella sonnei genome sequencing and phylogenetic analysis indicate recent global dissemination from Europe. Nature Genetics, 44 (9). 1056–1059. ISSN 1061-4036

NIHMS49152.pdf - Submitted Version

Download (3MB) | Preview


Shigella are human-adapted Escherichia coli that have gained the ability to invade the human gut mucosa and cause dysentery1,2, spreading efficiently via low-dose fecal-oral transmission3,4. Historically, S. sonnei has been predominantly responsible for dysentery in developed countries, but is now emerging as a problem in the developing world, apparently replacing the more diverse S. flexneri in areas undergoing economic development and improvements in water quality4-6. Classical approaches have shown S. sonnei is genetically conserved and clonal7. We report here whole-genome sequencing of 132 globally-distributed isolates. Our phylogenetic analysis shows that the current S. sonnei population descends from a common ancestor that existed less than 500 years ago and has diversified into several distinct lineages with unique characteristics. Our analysis suggests the majority of this diversification occurred in Europe, followed by more recent establishment of local pathogen populations in other continents predominantly due to the pandemic spread of a single, rapidly-evolving, multidrug resistant lineage.

Item type: Article
ID code: 41874
Keywords: shigella sonnei genome sequencing, phylogenetic analysis, global dissemination, europe, Pharmacy and materia medica, Genetics
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Pure Administrator
Date Deposited: 02 Nov 2012 05:45
Last modified: 30 Sep 2015 20:02
Related URLs:

Actions (login required)

View Item View Item