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Gold nanorods for applications in biological imaging

Zhang, Y. and Yu, J. and Birch, D. J. S. and Chen, Y. (2011) Gold nanorods for applications in biological imaging. [Proceedings Paper]

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Abstract

Two-Photon luminescence (TPL) from gold nanorods shows considerable potential in biological imaging for high resolution, low photo-damage, tunable near infra-red (NIR) longitudinal band, polarization dependence, ability to conjugate to bio-molecules and low toxicity. Here we demonstrate the application of gold nanorods as TPL imaging agents by studying the gold nanorods taken up by Madin-Darby canine kidney (MDCK) cells using both confocal imaging and fluorescence lifetime imaging microscopy (FLIM). The characteristic luminescence lifetime of gold nanorods is found to be less than 100 ps, which can be used to distinguish gold nanorods from other fluorescent labels and endogenous fluorophores in lifetime imaging.

Item type: Proceedings Paper
ID code: 41578
Keywords: time, surface plasmon, contrast agents, cells, photoluminescence, optical-properties, nanoparticles, gold nanorods, metal-enhanced fluroescence, luminescence, microscopy, two-photon luminescence, fluorescence lifetime imaging, emission, biological imaging, Pharmacy and materia medica, Physics
Subjects: Medicine > Pharmacy and materia medica
Science > Physics
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Science > Physics
Technology and Innovation Centre > Bionanotechnology
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Depositing user: Pure Administrator
Date Deposited: 19 Oct 2012 12:59
Last modified: 27 Mar 2014 11:31
URI: http://strathprints.strath.ac.uk/id/eprint/41578

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