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Eumelanin fibrils

McQueenie, Ross and Sutter, Jens and Karolin, Jan and Birch, David J. S. (2012) Eumelanin fibrils. Journal of Biomedical Optics, 17 (7). -. ISSN 1083-3668

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Abstract

We describe the auto-oxidation of 3, 4-dihydroxy-L-phenylalanine (L-DOPA) in the synthesis of eumelanin to spontaneously produce fibrils upon drying. The self-assembled fibrils are of characteristic diameter similar to 1 to 2 mu m, composed of filaments, and are unidirectional, apart from branches that are formed at typically an angle of 20 to 22 deg. The fibrils are characterized using fluorescence spectroscopy, fluorescence decay times, scanning electron microscopy, atomic force microscopy, and fluorescence lifetime imaging microscopy. The fibrils mimic natural melanin in consisting of core eumelanin with efficient nonradiative properties, but they also display pockets of electronically isolated species with higher radiative rates on the nanosecond timescale. Eumelanin fibrils formed occasionally in solution are tentatively attributed to a scaffold of bacteria or fungus. Fabricating and characterizing novel synthetic eumelanin structures such as fibrils are of interest in helping to reveal a functional structure for eumelanin, in understanding its photophysics, in learning more about L-DOPA as it is used in the treatment of Parkinson's disease, and in producing novel materials which might embody some of the diverse properties of eumelanin.

Item type: Article
ID code: 41441
Keywords: electron microscopy, atomic force microscopy , fluorescence lifetime imaging microscopy , biomedical optics, Solid state physics. Nanoscience, Optics. Light, Biomedical Engineering, Biomaterials, Electronic, Optical and Magnetic Materials, Atomic and Molecular Physics, and Optics
Subjects: Science > Physics > Solid state physics. Nanoscience
Science > Physics > Optics. Light
Department: Faculty of Science > Physics
Technology and Innovation Centre > Bionanotechnology
Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 15 Oct 2012 11:00
    Last modified: 03 Jul 2014 14:30
    URI: http://strathprints.strath.ac.uk/id/eprint/41441

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