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Cyclic phosphatidic acid and its analogues can regulate ERK1/2 activity via LPA receptors

Grzelczyk, A. and Rytczak, P. and Okruszek, A. and Koziolkiewicz, M. and Pyne, N. and Pyne, S. (2011) Cyclic phosphatidic acid and its analogues can regulate ERK1/2 activity via LPA receptors. Chemistry and Physics of Lipids, 164 (Supple). S32. ISSN 0009-3084

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Abstract

Cyclic phosphatidic acid (1-acyl-sn-glycerol-2,3 cyclic phosphate, cPA) and lysophosphatidic acid (LPA) are bioactive lipid mediators belonging to the small glycerophospholipids. Recent studies have shown that these compounds possess contrasting biological activities: LPA induces tumor cell proliferation and motility, while cPA suppresses metastasis and invasion of cancer cells. There are known at least eight LPA receptors involved in LPA signaling, however selective receptors of cPA are still unknown.

Item type: Article
ID code: 41415
Keywords: bioactive lipid mediators, tumor cell, LPA receptors, Pharmacy and materia medica, Biochemistry, Cell Biology, Organic Chemistry, Molecular Biology
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 12 Oct 2012 20:59
    Last modified: 05 Sep 2014 18:00
    URI: http://strathprints.strath.ac.uk/id/eprint/41415

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