Grzelczyk, A. and Rytczak, P. and Okruszek, A. and Koziolkiewicz, M. and Pyne, N. and Pyne, S. (2011) Cyclic phosphatidic acid and its analogues can regulate ERK1/2 activity via LPA receptors. Chemistry and Physics of Lipids, 164 (Supple). S32. ISSN 0009-3084Full text not available in this repository. (Request a copy from the Strathclyde author)
Cyclic phosphatidic acid (1-acyl-sn-glycerol-2,3 cyclic phosphate, cPA) and lysophosphatidic acid (LPA) are bioactive lipid mediators belonging to the small glycerophospholipids. Recent studies have shown that these compounds possess contrasting biological activities: LPA induces tumor cell proliferation and motility, while cPA suppresses metastasis and invasion of cancer cells. There are known at least eight LPA receptors involved in LPA signaling, however selective receptors of cPA are still unknown.
|Keywords:||bioactive lipid mediators, tumor cell, LPA receptors, Pharmacy and materia medica, Biochemistry, Cell Biology, Organic Chemistry, Molecular Biology|
|Subjects:||Medicine > Pharmacy and materia medica|
|Department:||Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences|
|Depositing user:||Pure Administrator|
|Date Deposited:||12 Oct 2012 19:59|
|Last modified:||30 Apr 2016 00:17|