Picture of a sphere with binary code

Making Strathclyde research discoverable to the world...

The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs. It exposes Strathclyde's world leading Open Access research to many of the world's leading resource discovery tools, and from there onto the screens of researchers around the world.

Explore Strathclyde Open Access research content

Axisymmetric polydimethysiloxane microchannels for in vitro hemodynamic studies

Lima, Rui and Oliveira, Monica and Ishikawa, T. and Kaji, H. and Tanaka, S. and Nishizawa, M. and Yamaguchi, T. (2009) Axisymmetric polydimethysiloxane microchannels for in vitro hemodynamic studies. Biofabrication, 1 (3). ISSN 1758-5082

[img] PDF
Oliveira_M_Pure_Axisymmetric_polydimethysiloxane_microchannels_for_in_vitro_hemodynamic_studies_Sep_2009.pdf - Draft Version

Download (997kB)

Abstract

The current microdevices used for biomedical research are often manufactured using microelectromechanical systems (MEMS) technology. Although it is possible to fabricate precise and reproducible rectangular microchannels using soft lithography techniques, this kind of geometry may not reflect the actual physiology of the microcirculation. Here, we present a simple method to fabricate circular polydimethysiloxane (PDMS) microchannels aiming to mimic an in vivo microvascular environment and suitable for state-of-the-art microscale flow visualization techniques, such as confocal µPIV/PTV. By using a confocal µPTV system individual red blood cells (RBCs) were successfully tracked trough a 75 µm circular PDMS microchannel. The results show that RBC lateral dispersion increases with the volume fraction of RBCs in the solution, i.e. with the hematocrit.