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Axisymmetric polydimethysiloxane microchannels for in vitro hemodynamic studies

Lima, Rui and Oliveira, Monica and Ishikawa, T. and Kaji, H. and Tanaka, S. and Nishizawa, M. and Yamaguchi, T. (2009) Axisymmetric polydimethysiloxane microchannels for in vitro hemodynamic studies. Biofabrication, 1 (3). ISSN 1758-5082

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    Abstract

    The current microdevices used for biomedical research are often manufactured using microelectromechanical systems (MEMS) technology. Although it is possible to fabricate precise and reproducible rectangular microchannels using soft lithography techniques, this kind of geometry may not reflect the actual physiology of the microcirculation. Here, we present a simple method to fabricate circular polydimethysiloxane (PDMS) microchannels aiming to mimic an in vivo microvascular environment and suitable for state-of-the-art microscale flow visualization techniques, such as confocal µPIV/PTV. By using a confocal µPTV system individual red blood cells (RBCs) were successfully tracked trough a 75 µm circular PDMS microchannel. The results show that RBC lateral dispersion increases with the volume fraction of RBCs in the solution, i.e. with the hematocrit.

    Item type: Article
    ID code: 41374
    Keywords: microchannels, polydimethysiloxane (PDMS) , flow visualisation, Mechanical engineering and machinery, Mechanical Engineering, Biomedical Engineering, Industrial and Manufacturing Engineering, Fluid Flow and Transfer Processes, Computational Mechanics, Computer Vision and Pattern Recognition
    Subjects: Technology > Mechanical engineering and machinery
    Department: Faculty of Engineering > Mechanical and Aerospace Engineering
    Related URLs:
      Depositing user: Pure Administrator
      Date Deposited: 11 Oct 2012 11:59
      Last modified: 06 Sep 2014 13:57
      URI: http://strathprints.strath.ac.uk/id/eprint/41374

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