MacMillan, Donna Stephanie and Murray, Jane and Sneddon, Helen F. and Jamieson, Craig and Watson, Allan (2012) Replacement of dichloromethane within chromatographic purification : a guide to alternative solvents. Green Chemistry, 14 (11). pp. 3016-3019. ISSN 1463-9262
C2GC36378J.pdf - Published Version
Available under License Unspecified.
Download (655kB) | Preview
Replacement of dichloromethane as the bulk medium within chromatographic purification has been evaluated with a broad range of molecules containing functionality common within Medicinal Chemistry programmes. Analysis of the data set has generated a set of general guidelines to assist in the selection of alternative solvents for CH2Cl2 as the bulk media in these ubiquitously employed processes.
|Keywords:||green chemistry, purification, alternative solvents, chromatography , replacement, dichloromethane , chromatographic purification , Chemistry, Environmental Chemistry, Pollution|
|Subjects:||Science > Chemistry|
|Department:||Faculty of Science > Pure and Applied Chemistry|
|Depositing user:||Pure Administrator|
|Date Deposited:||09 Oct 2012 10:59|
|Last modified:||21 May 2015 14:58|
Actions (login required)