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Replacement of dichloromethane within chromatographic purification : a guide to alternative solvents

MacMillan, Donna Stephanie and Murray, Jane and Sneddon, Helen F. and Jamieson, Craig and Watson, Allan (2012) Replacement of dichloromethane within chromatographic purification : a guide to alternative solvents. Green Chemistry, 14 (11). pp. 3016-3019. ISSN 1463-9262

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Abstract

Replacement of dichloromethane as the bulk medium within chromatographic purification has been evaluated with a broad range of molecules containing functionality common within Medicinal Chemistry programmes. Analysis of the data set has generated a set of general guidelines to assist in the selection of alternative solvents for CH2Cl2 as the bulk media in these ubiquitously employed processes.

Item type: Article
ID code: 41364
Keywords: green chemistry, purification, alternative solvents, chromatography , replacement, dichloromethane , chromatographic purification , Chemistry, Environmental Chemistry, Pollution
Subjects: Science > Chemistry
Department: Faculty of Science > Pure and Applied Chemistry
Depositing user: Pure Administrator
Date Deposited: 09 Oct 2012 10:59
Last modified: 15 Apr 2015 11:09
URI: http://strathprints.strath.ac.uk/id/eprint/41364

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