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Replacement of dichloromethane within chromatographic purification : a guide to alternative solvents

MacMillan, Donna Stephanie and Murray, Jane and Sneddon, Helen F. and Jamieson, Craig and Watson, Allan (2012) Replacement of dichloromethane within chromatographic purification : a guide to alternative solvents. Green Chemistry, 14 (11). pp. 3016-3019. ISSN 1463-9262

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Abstract

Replacement of dichloromethane as the bulk medium within chromatographic purification has been evaluated with a broad range of molecules containing functionality common within Medicinal Chemistry programmes. Analysis of the data set has generated a set of general guidelines to assist in the selection of alternative solvents for CH2Cl2 as the bulk media in these ubiquitously employed processes.