Picture of athlete cycling

Open Access research with a real impact on health...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the Physical Activity for Health Group based within the School of Psychological Sciences & Health. Research here seeks to better understand how and why physical activity improves health, gain a better understanding of the amount, intensity, and type of physical activity needed for health benefits, and evaluate the effect of interventions to promote physical activity.

Explore open research content by Physical Activity for Health...

A delay differential equation mathematical model for the control of the hormonal system of the hypothalamus, the pituitary and the testis in man

Greenhalgh, David and Khan, Qamar (2008) A delay differential equation mathematical model for the control of the hormonal system of the hypothalamus, the pituitary and the testis in man. In: Fifth World Congress of Nonlinear Analysts, 2011-03-31.

Full text not available in this repository. Request a copy from the Strathclyde author

Abstract

In this paper we develop previously studied mathematical models of the regulation of testosterone by luteinizing hormone and luteinizing hormone release hormone in the human body. We propose a delay differential equation mathematical model which improves on earlier simpler models by taking into account observed experimental facts. We show that our model has four possible equilibria, but only one unique equilibrium where all three hormones are present. We perform stability and Hopf bifurcation analyses on the equilibrium where all three hormones are present. With no time delay this equilibrium is unstable, but as the time delay increases through an infinite sequence of positive values Hopf bifurcation occurs repeatedly. This is of practical interest as biological evidence shows that the levels of these hormones in the body oscillate periodically. We next discuss stability of the other equilibria heuristically using analytical methods. Then we describe simulations with realistic parameter values and show that our model can mimic the regular fluctuations of the three hormones in the body and explore numerically some of our heuristic conjectures. A brief discussion concludes the paper.