Picture of virus under microscope

Research under the microscope...

The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

Explore SIPBS research

An RNA splicing enhancer that does not act by looping

Lewis, Helen and Perrett, Andrew and Burley, Glenn and Eperon, Ian (2012) An RNA splicing enhancer that does not act by looping. Angewandte Chemie International Edition, 51 (39). 9800–9803. ISSN 1433-7851

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

Do the proteins bound to an enhancer site on pre-mRNA interact directly with the splice site by diffusion (looping), as is generally accepted, or does the intervening RNA play a role (see scheme)? By inserting a PEG linker between an enhancer sequence and alternative splice sites, the interaction of these two elements can be studied. Intervening RNA was essential for the enhancer activity, which rules out the looping model.