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An RNA splicing enhancer that does not act by looping

Lewis, Helen and Perrett, Andrew and Burley, Glenn and Eperon, Ian (2012) An RNA splicing enhancer that does not act by looping. Angewandte Chemie International Edition, 51 (39). 9800–9803. ISSN 1433-7851

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Abstract

Do the proteins bound to an enhancer site on pre-mRNA interact directly with the splice site by diffusion (looping), as is generally accepted, or does the intervening RNA play a role (see scheme)? By inserting a PEG linker between an enhancer sequence and alternative splice sites, the interaction of these two elements can be studied. Intervening RNA was essential for the enhancer activity, which rules out the looping model.

Item type: Article
ID code: 41207
Keywords: click chemistry, pre-RNA splicing, mRNA, oligonucleotides, splicing enhancers, looping, rna splicing enhancer, Chemistry, Chemistry(all)
Subjects: Science > Chemistry
Department: Faculty of Science > Pure and Applied Chemistry
Technology and Innovation Centre > Bionanotechnology
Related URLs:
Depositing user: Pure Administrator
Date Deposited: 20 Sep 2012 14:16
Last modified: 27 Mar 2014 10:31
URI: http://strathprints.strath.ac.uk/id/eprint/41207

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