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World class computing and information science research at Strathclyde...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including by researchers from the Department of Computer & Information Sciences involved in mathematically structured programming, similarity and metric search, computer security, software systems, combinatronics and digital health.

The Department also includes the iSchool Research Group, which performs leading research into socio-technical phenomena and topics such as information retrieval and information seeking behaviour.

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The need for drugs and delivery systems

Wilson, Clive (2011) The need for drugs and delivery systems. In: Fundamentals and applications of controlled release drug delivery. Advances in Delivery Science and Technology . Springer, New York, pp. 3-18. ISBN 9781461408802

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Abstract

Disease processes and ageing require therapeutic intervention to ameliorate or eliminate, when possible, the effects of pathologies on everyday living. Ageing is associated with a gradual degeneration and subsequent alteration of the balance of the body’s control systems. Drugs are useful therapeutic agents that interact with cellular targets to produce an effect that amplifies or more usually blocks cellular processes selectively, provided that dose and access are sufficient. This redresses the balance in ageing and pathology to increase patient comfort. The relationship between presentation of the drug and effect can be defined mathematically and is used to calculate the target window for administration; however, both pathological processes and ageing can alter exposure as changes occur in structure and function of the body, leading to decreased control of drug effectiveness.