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Positively charged silver nanoparticles and their effect on surface-enhanced Raman scattering of dye-labelled oligonucleotides

van Lierop, Danny and Krpetic, Zeljka and Guerrini, Luca and Larmour, Iain A. and Dougan, Jennifer A. and Faulds, Karen and Graham, Duncan (2012) Positively charged silver nanoparticles and their effect on surface-enhanced Raman scattering of dye-labelled oligonucleotides. Chemical Communications, 48 (66). pp. 8192-8194. ISSN 1359-7345

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Abstract

Improved positively charged nanoparticles are described to provide a simplified SERS substrate for DNA detection. Complete flocculation of the nanoparticles is prevented due to the controlled analyte induced aggregation. This provides a stable aggregation state which significantly extends the analysis window simplifying DNA detection by SERS.