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Advancing schizophrenia drug discovery : optimizing rodent models to bridge the translational gap

Pratt, Judith and Winchester, Catherine and Dawson, Neil and Morris, Brian (2012) Advancing schizophrenia drug discovery : optimizing rodent models to bridge the translational gap. Nature Reviews Drug Discovery, 11 (7). pp. 560-579. ISSN 1474-1776

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Abstract

Although our knowledge of the pathophysiology of schizophrenia has increased, treatments for this devastating illness remain inadequate. Here, we critically assess rodent models and behavioural end points used in schizophrenia drug discovery and discuss why these have not led to improved treatments. We provide a perspective on how new models, based on recent advances in the understanding of the genetics and neural circuitry underlying schizophrenia, can bridge the translational gap and lead to the development of more effective drugs. We conclude that previous serendipitous approaches should be replaced with rational strategies for drug discovery in integrated preclinical and clinical programmes. Validation of drug targets in disease-based models that are integrated with translationally relevant end point assessments will reduce the current attrition rate in schizophrenia drug discovery and ultimately lead to therapies that tackle the disease process.

Item type: Article
ID code: 40852
Keywords: disease models, translational medicine, schizophrenia, genetic models, drug discovery research, brain circuitry, animal, schizophrenia , drug discovery , rodent models , translational gap , Pharmacy and materia medica, Medicine(all)
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 10 Aug 2012 09:32
    Last modified: 05 Sep 2014 17:23
    URI: http://strathprints.strath.ac.uk/id/eprint/40852

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