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Gelatine and gelatine/elastin nanocomposites for vascular grafts : processing and characterisation

Lamprou, Dimitrios and Zhdan, P and Labeed, F and Lekakou, C (2011) Gelatine and gelatine/elastin nanocomposites for vascular grafts : processing and characterisation. Journal of Biomaterials Applications, 26 (2). pp. 209-226.

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Abstract

This study involves the preparation, microstructural, physical, mechanical, and biological characterization of novel gelatine and gelatine/elastin gels for their use in the tissue engineering of vascular grafts. Gelatine and gelatine/elastin nanocomposite gels were prepared via a sol-gel process, using soluble gelatine. Gelatine was subsequently cross-linked by leaving the gels in 1% glutaraldehyde. The cross-linking time was optimized by assessing the mass loss of the cross-linked gels in water and examining their mechanical properties in dynamic mechanical tests. Atomic force microscopy (AFM) studies revealed elastin nanodomains, homogeneously distributed and embedded in a bed of gelatine nanofibrils in the 30/70 elastin/gelatine gel. It was concluded that the manufactured nanocomposite gels resembled natural arteries in terms of microstructure and stiffness. The biological characterization involved the culture of rat smooth muscle cells (SMCs) on tubular gelatine and gelatine/ elastin nanocomposite gels, and measurements of the scaffold diameter and the cell density as a function of time.

Item type: Article
ID code: 40713
Keywords: vascular, graft, gel, gelatine, composite, nanocomposite, Pharmacy and materia medica
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Technology and Innovation Centre > Continuous Manufacturing and Crystallisation (CMAC)
Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 03 Aug 2012 09:59
    Last modified: 12 Jun 2013 16:04
    URI: http://strathprints.strath.ac.uk/id/eprint/40713

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