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Optimising conditions for studying the acute effects of drugs on indices of cardiac contractility and on haemodynamics in anaesthetized guinea pigs

Mooney, Laura and Marks, Louise and Philp, Karen L and Skinner, Matthew and Coker, Susan J and Currie, Susan (2012) Optimising conditions for studying the acute effects of drugs on indices of cardiac contractility and on haemodynamics in anaesthetized guinea pigs. Journal of Pharmacological and Toxicological Methods, 66 (1). pp. 43-51.

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Abstract

Detecting adverse effects of drugs on cardiac contractility is becoming a priority in pre-clinical safety pharmacology. The aim of this work was to optimise conditions and explore the potential of using the anaesthetized guinea pig as an in vivo model.