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Optimising conditions for studying the acute effects of drugs on indices of cardiac contractility and on haemodynamics in anaesthetized guinea pigs

Mooney, Laura and Marks, Louise and Philp, Karen L and Skinner, Matthew and Coker, Susan J and Currie, Susan (2012) Optimising conditions for studying the acute effects of drugs on indices of cardiac contractility and on haemodynamics in anaesthetized guinea pigs. Journal of Pharmacological and Toxicological Methods, 66 (1). pp. 43-51.

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Abstract

Detecting adverse effects of drugs on cardiac contractility is becoming a priority in pre-clinical safety pharmacology. The aim of this work was to optimise conditions and explore the potential of using the anaesthetized guinea pig as an in vivo model.

Item type: Article
ID code: 40691
Notes: Copyright © 2012 Elsevier Inc. All rights reserved.
Keywords: anaesthesia, cardiac contractility, guinea pig, inotropes, isoprenaline, verapamil, Pharmacy and materia medica, Toxicology, Pharmacology
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
Depositing user: Pure Administrator
Date Deposited: 02 Aug 2012 14:47
Last modified: 27 Mar 2014 10:23
URI: http://strathprints.strath.ac.uk/id/eprint/40691

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