Duszenko, Michael and Ginger, Michael L. and Brennand, Ana and Gualdrón-López, Melisa and Colombo, María Isabel and Coombs, Graham H and Coppens, Isabelle and Jayabalasingham, Bamini and Langsley, Gordon and de Castro, Solange Lisboa and Menna-Barreto, Rubem and Mottram, Jeremy C and Navarro, Miguel and Rigden, Daniel J. and Romano, Patricia S. and Stoka, Veronika and Turk, Boris and Michels, Paul A.M. (2011) Autophagy in protists. Autophagy, 7 (2). pp. 127-158.Full text not available in this repository. (Request a copy from the Strathclyde author)
Autophagy is the degradative process by which eukaryotic cells digest their own components using acid hydrolases within the lysosome. Originally thought to function almost exclusively in providing starving cells with nutrients taken from their own cellular constituents, autophagy is in fact involved in numerous cellular events including differentiation, turnover of macromolecules and organelles, and defense against parasitic invaders. During the last 10-20 years, molecular components of the autophagic machinery have been discovered, revealing a complex interactome of proteins and lipids, which, in a concerted way, induce membrane formation to engulf cellular material and target it for lysosomal degradation. Here, our emphasis is autophagy in protists. We discuss experimental and genomic data indicating that the canonical autophagy machinery characterized in animals and fungi appeared prior to the radiation of major eukaryotic lineages. Moreover, we describe how comparative bioinformatics revealed that this canonical machinery has been subject to moderation, outright loss or elaboration on multiple occasions in protist lineages, most probably as a consequence of diverse lifestyle adaptations. We also review experimental studies illustrating how several pathogenic protists either utilize autophagy mechanisms or manipulate host-cell autophagy in order to establish or maintain infection within a host. The essentiality of autophagy for the pathogenicity of many parasites, and the unique features of some of the autophagy-related proteins involved, suggest possible new targets for drug discovery. Further studies of the molecular details of autophagy in protists will undoubtedly enhance our understanding of the diversity and complexity of this cellular phenomenon and the opportunities it offers as a drug target.
|Keywords:||eukaryotic cells, acid hydrolases, lysosome, Pharmacy and materia medica, Cell Biology, Molecular Biology|
|Subjects:||Medicine > Pharmacy and materia medica|
|Department:||Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences|
|Depositing user:||Pure Administrator|
|Date Deposited:||09 Jul 2012 13:02|
|Last modified:||06 Aug 2016 00:05|