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MKP-2 : out of the DUSP-bin and back into the limelight

Lawan, A. and Torrance, E. and Al-Harthi, S. and Shweash, M. and Alnasser, S. and Neamatallah, T. and Schroeder, J. and Plevin, R. (2012) MKP-2 : out of the DUSP-bin and back into the limelight. Biochemical Society Transactions, 40. pp. 235-239. ISSN 0300-5127

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Abstract

The MKPs (mitogen-activated protein kinase phosphatases) are a family of at least ten DUSPs (dual-specificity phosphatases) which function to terminate the activity of the MAPKs (mitogen-activated protein kinases). Several members have already been demonstrated to have distinct roles in immune function, cancer, fetal development and metabolic disorders. One DUSP of renewed interest is the inducible nuclear phosphatase MKP-2, which dephosphorylates both ERK (extracellular-signal-regulated kinase) and JNK (c-Jun N-terminal kinase) in vitro. Recently, the understanding of MKP-2 function has been advanced due to the development of mouse knockout models, which has resulted in the discovery of novel roles for MKP-2 in the regulation of sepsis, infection and cell-cycle progression that are distinct from those of other DUSPs. However, many functions for MKP-2 still await to be characterized

Item type: Article
ID code: 40273
Keywords: innate immune-responses, activated protein-kinase, proliferation, mitogen-activated protein kinase phosphatase 2 (MKP-2), immunity, phosphatase, dual-specificity phosphatase (DUSP), mitogen-activated protein kinase (MAPK), cancer, DUSP-bin, limelight, mkp-2, Pharmacy and materia medica, Biochemistry
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
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Depositing user: Pure Administrator
Date Deposited: 29 Jun 2012 15:45
Last modified: 05 Sep 2014 16:33
URI: http://strathprints.strath.ac.uk/id/eprint/40273

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