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Efficacy in vivo of a cancer therapy strategy combining HSV1716 mediated oncolysis with gene transfer and targeted radiotherapy

Sorensen, Annette and Mairs, Robert J. and Braidwood, Lynne and Joyce, Craig and Conner, Joe and Pimlott, Sally and Brown, S. Moira and Boyd, Marie (2012) Efficacy in vivo of a cancer therapy strategy combining HSV1716 mediated oncolysis with gene transfer and targeted radiotherapy. Mutagenesis, 27 (1). pp. 134-135. ISSN 0267-8357

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Abstract

Oncolytic herpes viruses have show promise for the treatment of cancer however it is unlikely that the optimal application of these viruses will be as single therapeutic agents. An alternative strategy would be to utilise these viruses to deliver therapeutic transgenes and enhance their tumour cell killing capacity.