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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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Activation of the noradrenaline transporter gene using the radiation-inducible WAF1-1 promoter sensitizes tumour cells to [I-131] MIBG targeted radiotherapy

McCluskey, A. G. and Mairs, R. J. and Robson, T. and Hirst, D. G. and Boyd, M. (2012) Activation of the noradrenaline transporter gene using the radiation-inducible WAF1-1 promoter sensitizes tumour cells to [I-131] MIBG targeted radiotherapy. Mutagenesis, 27 (1). p. 131. ISSN 0267-8357

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Abstract

Radiotherapy given in combination with gene transfer is a promising approach for the treatment of cancer. However, progress in this field depends upon achieving the selective expression of therapeutic transgenes in tumours. Therefore, radiation-inducible gene promoters have attracted interest because they may enable temporal and spatial gene activation.