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Activation of the noradrenaline transporter gene using the radiation-inducible WAF1-1 promoter sensitizes tumour cells to [I-131] MIBG targeted radiotherapy

McCluskey, A. G. and Mairs, R. J. and Robson, T. and Hirst, D. G. and Boyd, M. (2012) Activation of the noradrenaline transporter gene using the radiation-inducible WAF1-1 promoter sensitizes tumour cells to [I-131] MIBG targeted radiotherapy. Mutagenesis, 27 (1). p. 131. ISSN 0267-8357

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Abstract

Radiotherapy given in combination with gene transfer is a promising approach for the treatment of cancer. However, progress in this field depends upon achieving the selective expression of therapeutic transgenes in tumours. Therefore, radiation-inducible gene promoters have attracted interest because they may enable temporal and spatial gene activation.

Item type: Article
ID code: 40162
Keywords: noradrenaline transporter, radiotherapy, Pharmacy and materia medica, Genetics, Genetics(clinical), Health, Toxicology and Mutagenesis, Toxicology
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Technology and Innovation Centre > Advanced Science and Technology
Technology and Innovation Centre > Bionanotechnology
Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 22 Jun 2012 09:29
    Last modified: 05 Sep 2014 16:26
    URI: http://strathprints.strath.ac.uk/id/eprint/40162

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