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Selective uncoupling of individual mitochondria within a cell using a mitochondria-targeted photoactivated protonophore

Chalmers, Susan and Caldwell, S.T. and Quin, C and Prime, T.A. and James, A.M. and Cairns, Alan and Murphy, M.P. and McCarron, John and Hartley, R.C. (2012) Selective uncoupling of individual mitochondria within a cell using a mitochondria-targeted photoactivated protonophore. Journal of the American Chemical Society, 134 (2). pp. 758-761.

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Abstract

Depolarization of an individual mitochondrion or small clusters of mitochondria within cells has been achieved using a photoactivatable probe. The probe is targeted to the matrix of the mitochondrion by an alkyltriphenylphosphonium lipophilic cation and releases the protonophore 2,4-dinitrophenol locally in predetermined regions in response to directed irradiation with UV light via a local photolysis system. This also provides a proof of principle for the general temporally and spatially controlled release of bioactive molecules, pharmacophores, or toxins to mitochondria with tissue, cell, or mitochondrion specificity.

Item type: Article
ID code: 40059
Keywords: mitochondria , photoactivated protonophore , pharmacophores , mitochondrion, Therapeutics. Pharmacology, Biochemistry, Colloid and Surface Chemistry, Chemistry(all), Catalysis
Subjects: Medicine > Therapeutics. Pharmacology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
Depositing user: Pure Administrator
Date Deposited: 14 Jun 2012 15:17
Last modified: 27 Mar 2014 10:11
URI: http://strathprints.strath.ac.uk/id/eprint/40059

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