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Measuring protein dynamics with ultrafast two-dimensional infrared spectroscopy

Adamczyk, Katrin and Candelaresi, Marco and Robb, Kirsty and Gumiero, Andrea and Walsh, Martin A. and Parker, Anthony W. and Hoskisson, Paul A. and Tucker, Nicholas P. and Hunt, Neil T. (2012) Measuring protein dynamics with ultrafast two-dimensional infrared spectroscopy. Measurement Science and Technology, 23 (6). ISSN 0957-0233

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Recent advances in the methodology and application of ultrafast two-dimensional infrared (2D-IR) spectroscopy to biomolecular systems are reviewed. A description of the 2D-IR technique and the molecular contributions to the observed spectra are presented followed by a discussion of recent literature relating to the use of 2D-IR and associated approaches for measuring protein dynamics. In particular, these include the use of diatomic ligand groups for measuring haem protein dynamics, isotopic labelling strategies and the use of vibrational probe groups. The final section reports on the current state of the art regarding the use of 2D-IR methods to provide insights into biological reaction mechanisms.