Devadoss, Anitha and Dennany, Lynn and Dickinson, Calum and Keyes, Tia E and Forster, Robert J. (2012) Highly sensitive detection of NADH using electrochemiluminescent nanocomposites. Electrochemistry Communications, 19. pp. 43-45. ISSN 1388-2481Full text not available in this repository. (Request a copy from the Strathclyde author)
Electrodes, modified with [Ru(bpy)2PVP10](ClO4)2 metallopolymer:gold nanoparticle composites, are used for the high sensitivity detection of nicotinamide adenine dinucleotide, NADH, using electrochemiluminescence, ECL; bpy is 2,2-bipyridyl and PVP is poly (4-vinylpyridine). Incorporation of 12.5 nm gold nanoparticles protected with 4-dimethylaminopyridine, DMAP-AuNPs, causes the overall ECL efficiency to decrease with increasing nanoparticle loading. However, the absolute emission intensity and signal-to-noise ratio are both higher for the nanocomposite than the parent metallopolymer. The ECL intensity depends linearly on [NADH] from 10 fM to 10 M with a limit of detection, LOD, of 5 fM. The wide dynamic range and low limit of detection makes these nanocomposite films attractive for biosensor development.
|Keywords:||nanocomposite , electrochemiluminescence, modified electrode, metal enhanced luminescence; , metallopolymer, Physical and theoretical chemistry, Electrochemistry|
|Subjects:||Science > Chemistry > Physical and theoretical chemistry|
|Department:||Faculty of Science > Pure and Applied Chemistry|
|Depositing user:||Pure Administrator|
|Date Deposited:||30 May 2012 14:21|
|Last modified:||27 Apr 2016 18:33|