Picture of a black hole

Strathclyde Open Access research that creates ripples...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of research papers by University of Strathclyde researchers, including by Strathclyde physicists involved in observing gravitational waves and black hole mergers as part of the Laser Interferometer Gravitational-Wave Observatory (LIGO) - but also other internationally significant research from the Department of Physics. Discover why Strathclyde's physics research is making ripples...

Strathprints also exposes world leading research from the Faculties of Science, Engineering, Humanities & Social Sciences, and from the Strathclyde Business School.

Discover more...

Highly sensitive detection of NADH using electrochemiluminescent nanocomposites

Devadoss, Anitha and Dennany, Lynn and Dickinson, Calum and Keyes, Tia E and Forster, Robert J. (2012) Highly sensitive detection of NADH using electrochemiluminescent nanocomposites. Electrochemistry Communications, 19. pp. 43-45. ISSN 1388-2481

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

Electrodes, modified with [Ru(bpy)2PVP10](ClO4)2 metallopolymer:gold nanoparticle composites, are used for the high sensitivity detection of nicotinamide adenine dinucleotide, NADH, using electrochemiluminescence, ECL; bpy is 2,2-bipyridyl and PVP is poly (4-vinylpyridine). Incorporation of 12.5 nm gold nanoparticles protected with 4-dimethylaminopyridine, DMAP-AuNPs, causes the overall ECL efficiency to decrease with increasing nanoparticle loading. However, the absolute emission intensity and signal-to-noise ratio are both higher for the nanocomposite than the parent metallopolymer. The ECL intensity depends linearly on [NADH] from 10 fM to 10 M with a limit of detection, LOD, of 5 fM. The wide dynamic range and low limit of detection makes these nanocomposite films attractive for biosensor development.