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Protein turnover and differentiation in Leishmania.

Besteiro, Sébastien and Williams, Roderick and Coombs, Graham and Mottram, Jeremy (2007) Protein turnover and differentiation in Leishmania. International Journal for Parasitology, 37 (10). 1063–1075. ISSN 0020-7519

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Abstract

Leishmania occurs in several developmental forms and thus undergoes complex cell differentiation events during its life-cycle. Those are required to allow the parasite to adapt to the different environmental conditions. The sequencing of the genome of L. major has facilitated the identification of the parasite’s vast arsenal of proteolytic enzymes, a few of which have already been carefully studied and found to be important for the development and virulence of the parasite. This review focuses on these peptidases and their role in the cellular differentiation of Leishmania through their key involvement in a variety of degradative pathways in the lysosomal and autophagy networks.

Item type: Article
ID code: 39797
Keywords: Leishmania, differentiation, protease, peptidase, genome, Pharmacy and materia medica, Infectious Diseases, Parasitology
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 29 May 2012 10:32
    Last modified: 05 Sep 2014 16:04
    URI: http://strathprints.strath.ac.uk/id/eprint/39797

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