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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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Multi-nuclear platinum complexes encapsulated in cucurbit[n]uril as an approach to reduce toxicity in cancer treatment

Wheate, N.J. and Day, A.I. and Blanch, R.J. and Arnold, A.P. and Cullinane, C. and Collins, J.G. (2004) Multi-nuclear platinum complexes encapsulated in cucurbit[n]uril as an approach to reduce toxicity in cancer treatment. Chemical Communications (London), 12. pp. 1424-1425. ISSN 0009-241X

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Abstract

The dinuclear platinum complex trans-[{Pt(NH3)2Cl}2μ-dpzm]2+ (di-Pt) binds inside cucurbit[7]uril with slow exchange kinetics which does not significantly affect the cytotoxicity of the dinuclear complex but reactivity at the platinum centre is reduced.