Brown, Samantha J and Corr, Stuart and Percy, Jonathan (2000) Fluorinated succinic acid derivatives from new refrigerants via ozonolysis of haloalkenes. Tetrahedron Letters, 41 (27). pp. 5269-5273. ISSN 0040-4039Full text not available in this repository. (Request a copy from the Strathclyde author)
Fluoro- and di-fluoro allylic alcohols obtained from HFC-134a and HCFC-133a were transformed through [3,3]-sigmatropic rearrangements into 3-fluoro-4-halo-4-alkenoates with variable substitution at the 2- and 3-positions. Ozonolysis of the haloalkenes afforded the corresponding acyl halides which could be trapped with nucleophiles to afford fluorinated succinic acid derivatives in which the two carboxylic acid groups were differentiated.
|Keywords:||allylic alcohols, ozonolysis, haloalkenes, Chemistry, Biochemistry, Organic Chemistry, Drug Discovery|
|Subjects:||Science > Chemistry|
|Department:||Faculty of Science > Pure and Applied Chemistry|
|Depositing user:||Pure Administrator|
|Date Deposited:||03 Apr 2012 15:40|
|Last modified:||22 Mar 2017 12:03|