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In vitro activity of extracts and constituents of Pelargonium against rapidly-growing mycobacteria

Seidel, Veronique and Taylor, Peter W (2004) In vitro activity of extracts and constituents of Pelargonium against rapidly-growing mycobacteria. International Journal of Antimicrobial Agents, 23 (6). pp. 613-619. ISSN 0924-8579

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Extracts of the roots of plants of the Geraniaceae family have been used for many years in South Africa as native herbal remedies and there is circumstantial evidence for efficacy in the treatment of pulmonary tuberculosis. We have examined dried roots of Pelargonium reniforme and P. sidoides for antibacterial activity against rapidly growing mycobacteria. Fractions with activity against Mycobacterium aurum and M. smegmatis were obtained from both plant species by bioassay-guided fractionation of n-hexane extracts and were found to contain mixtures of straight-chain fatty acids. Analysis by gas chromatography–mass spectrometry (GC–MS) of the corresponding fatty acid methyl esters revealed structures with chain lengths ranging from C12 to C26. Unsaturated compounds were analysed as the corresponding dimethyl disulfide adducts to determine double-bond positions. Active mixtures differed in the relative abundance of their components, but all contained 16:0 (palmitic), Δ9-18:1 (oleic) and Δ9,12-18:2 (linoleic acid) as the major components. When tested against M. aurum, M. smegmatis and other rapidly growing mycobacteria (M. fortuitum, M. abscessus and M. phlei), all saturated compounds except 12:0 were devoid of antimycobacterial activity, whereas unsaturated compounds showed antimycobacterial activity related to their degree of unsaturation, their chain length and the bacterial species tested. The most potent compound was linoleic acid, with MIC of 2 mg/l against M. aurum.

Item type: Article
ID code: 38725
Keywords: pelargonium, herbal remedy, mycobacteria, bioassay-guided fractionation, antibacterial fatty acids , Pharmacy and materia medica, Infectious Diseases, Microbiology (medical), Pharmacology (medical)
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Pure Administrator
Date Deposited: 27 Mar 2012 11:20
Last modified: 27 Jan 2016 13:41
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