Debbab, Abdessamad and Aly, Amal H. and Edrada-Ebel, Ruangelie and Wray, Victor and Pretsch, Alexander and Pescitelli, Gennaro and Kurtan, Tibor and Proksch, Peter (2012) New anthracene derivatives – structure elucidation and antimicrobial activity. European Journal of Organic Chemistry, 2012. pp. 1351-1359. ISSN 1434-193XFull text not available in this repository. (Request a copy from the Strathclyde author)
Three new anthracene derivatives, which include tetrahydroanthraquinone 1 and two tetrahydroanthraquinone heterodimers 2 and 3, were isolated from Stemphylium globuliferum, together with four known metabolites 4–7. Detailed analysis of the spectroscopic data allowed the unambiguous determination of the structures of 1 and 2 and a revision of the structure of alterporriol C and its atropisomer. Furthermore, alterporriol G, previously obtained as part of a mixture, was isolated in its pure form for the first time and its structure was also revised. The absolute configurations of 1, 2 and 3 were assigned by calculation of their CD spectra, which also allowed the configurational assignment of altersolanol A and the determination of the axial chirality of alterporriols D and E. All isolated compounds were analysed for their antimicrobial and cytotoxic activities. Compounds 1 and 5 inhibited the growth of most pathogenic microorganisms tested, whereas 2, 6 and 7 showed selective inhibition of bacteria but were inactive against fungi.
|Keywords:||natural products, antibiotics, structure elucidation, circular dichroism, quinone, Chemistry, Organic Chemistry, Physical and Theoretical Chemistry|
|Subjects:||Science > Chemistry|
|Department:||Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences|
|Depositing user:||Pure Administrator|
|Date Deposited:||23 Mar 2012 13:53|
|Last modified:||26 Aug 2016 02:35|