Picture of a black hole

Strathclyde Open Access research that creates ripples...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of research papers by University of Strathclyde researchers, including by Strathclyde physicists involved in observing gravitational waves and black hole mergers as part of the Laser Interferometer Gravitational-Wave Observatory (LIGO) - but also other internationally significant research from the Department of Physics. Discover why Strathclyde's physics research is making ripples...

Strathprints also exposes world leading research from the Faculties of Science, Engineering, Humanities & Social Sciences, and from the Strathclyde Business School.

Discover more...

Natural products isolation in modern drug discovery programs

Gray, Alexander I and Igoli, John O and Edrada-Ebel, Ruangelie (2012) Natural products isolation in modern drug discovery programs. Methods in Molecular Biology, 864. pp. 515-34.

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

Natural products play a vital role in drug discovery. They have served as the basic reference and initiators in drug discovery programs. Natural products as pure compounds have been involved in western medicine as drugs or lead compounds for drug discovery and development. In traditional medicine, they have been involved for a very long time as medicinal extracts, infusions, decoctions, or other therapeutic preparations. Modern drug discovery programs require an arsenal of drug candidate molecules in pure form whose activities (usually against cells or enzymes) are rapidly determined using high-throughput screening (HTS) and activities are expected in micro- (μM) to nanomolar (nM) levels. The difficulty in meeting today's standards for drug candidate molecules poses the question: are natural products still relevant in modern drug discovery programs? This and other issues, including the spectroscopic investigation of crude extracts, are discussed.