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Nucleotide cross-linking induced by photoreactions of novel platinum (IV) azide complexes

Parkinson, J.A. and Muller, P. and Shroder, B. and Kratochwil, N.A. and Coxall, R.A. and Parkin, A. and Parsons, S. and Sadler, P.J. (2003) Nucleotide cross-linking induced by photoreactions of novel platinum (IV) azide complexes. Angewandte Chemie, 42 (3). pp. 335-339.

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Abstract

Visible light irradiation of inert [PtIV(diam(m)ine)(diazide)] complexes leads to reductive elimination of the azide ligands, production of N2, and formation of bifunctional adducts with guanine bases of the type which are lethal to cancer cells.

Item type: Article
ID code: 38590
Keywords: photoreactions , novel platinum (IV) azide complexes , cancer cells, irradiation, Chemistry, Medicine(all)
Subjects: Science > Chemistry
Department: Faculty of Science > Pure and Applied Chemistry
Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 20 Mar 2012 12:22
    Last modified: 04 Sep 2014 19:22
    URI: http://strathprints.strath.ac.uk/id/eprint/38590

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