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Evaluation of invertebrate infection models for pathogenic corynebacteria

Ott, Lisa and McKenzie, Ashleigh and Baltazar, Teresa and Britting, Sabine and Bischof, Andrea and Burkovski, Andreas and Hoskisson, Paul (2012) Evaluation of invertebrate infection models for pathogenic corynebacteria. FEMS Immunology and Medical Microbiology. (In Press)

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Abstract

For several pathogenic bacteria, model systems for host–pathogen interactions were developed, which provide the possibility of quick and cost-effective high throughput screening of mutant bacteria for genes involved in pathogenesis. A number of different model systems, including amoeba, nematodes, insects, and fish, have been introduced, and it was observed that different bacteria respond in different ways to putative surrogate hosts, and distinct model systems might be more or less suitable for a certain pathogen. The aim of this study was to develop a suitable invertebrate model for the human and animal pathogens Corynebacterium diphtheriae,Corynebacterium pseudotuberculosis, and Corynebacterium ulcerans. The results obtained in this study indicate that Acanthamoeba polyphaga is not optimal as surrogate host, while both Caenorhabtitis elegans and Galleria larvae seem to offer tractable models for rapid assessment of virulence between strains. Caenorhabtitis elegans gives more differentiated results and might be the best model system for pathogenic corynebacteria, given the tractability of bacteria and the range of mutant nematodes available to investigate the host response in combination with bacterial virulence. Nevertheless, Galleria will also be useful in respect to innate immune responses to pathogens because insects offer a more complex cell-based innate immune system compared with the simple innate immune system of C. elegans.

Item type: Article
ID code: 38534
Keywords: pathogenic corynebacteria , invertebrates, Therapeutics. Pharmacology
Subjects: Medicine > Therapeutics. Pharmacology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 16 Mar 2012 10:33
    Last modified: 10 Jul 2012 13:42
    URI: http://strathprints.strath.ac.uk/id/eprint/38534

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