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The effect of nitrostyrene on cell proliferation and macrophage immune responses

Nic Daeid, N. and Carter, K.C. and Finnon, Y.S. and Waddell, R.J.H. and Robson, D.C. (2002) The effect of nitrostyrene on cell proliferation and macrophage immune responses. Immunopharmacology and Immunotoxicology, 24 (2). pp. 187-197. ISSN 0892-3973

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The use of mood enhancing drugs such as amphetamine and ecstasy are now prevalent in society. These compounds are known to produce serious psychological and physiological problems in users, which can, in some circumstances result in death. While there has been much research into the effects of these drugs on the body, little if any research has investigated the effect of the side products and synthetic reaction by-products which are a consequence of there illegal production. In the study the effects of nitrostyrene, a reaction by-product in one of the routes to synthesis of amphetamine sulphate, on cell viability and macrophage function was determined. Treatment with nitrostyrene at doses >0.75 µg/mL had a significant suppressive effect on the proliferation of stomach cancer lines. Treatment of macrophages with doses as high as 10 µg/mL did not effect cell viability. Nitrostyrene treatment of macrophages, stimulated with IFN γ and LPS, resulted in a dose dependent differential inhibition in IL12, IL6 and nitrite production, even using doses <0.5 µg/mL. Thus ranking of the three, on the basis of the suppressive effect obtained, is IL12 > nitrite > IL6. Thus ingestion of nitrostyrene contaminated ecstasy is likely to have a adverse effect on the immune responses of the recreational user.

Item type: Article
ID code: 38528
Keywords: cell proliferation , macrophage , macrophage immune responses, Chemistry, Immunology, Toxicology, Pharmacology, Immunology and Allergy
Subjects: Science > Chemistry
Department: Faculty of Science > Pure and Applied Chemistry
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Unknown Department
Depositing user: Pure Administrator
Date Deposited: 14 Mar 2012 16:44
Last modified: 10 Dec 2015 17:38

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