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Lack of effect of proteinase-activated receptor 2 (PAR2) deletion on the pathophysiological changes produced by lipopolysaccharide in the mouse:comparison with dexamethasone

Kazerani, H. and Plevin, R.J. and Kawagoe, J. and Kanke, T. and Furman, B.L. (2004) Lack of effect of proteinase-activated receptor 2 (PAR2) deletion on the pathophysiological changes produced by lipopolysaccharide in the mouse:comparison with dexamethasone. Journal of Pharmacy and Pharmacology, 56 (8). pp. 1015-20. ISSN 0022-3573

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Abstract

Four pentacyclic tritepenes were isolated from Combretum imberbe Engl. & Diels, of which two are novel glycosidic derivatives of 1α,3β,23-trihydroxyolean-12-en-29-oic acid (hydroxyimberbic acid). Terminalia stuhlmannii Engl. & Diels stem bark yielded two glycosides of hydroxyimberbic acid, one of which is reported for the first time. The structures of the isolated compounds were elucidated by spectroscopic methods. Several of the compounds had antibacterial activity, imberbic acid showing particularly potent activity against Mycobacterium fortuitum and Staphylococcus aureus.

Item type: Article
ID code: 38409
Keywords: proteinase-activated receptor-2 , lipopolysaccharide , dexamethasone, Pharmacy and materia medica, Pharmaceutical Science, Pharmacology
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 12 Mar 2012 15:14
    Last modified: 04 Sep 2014 19:31
    URI: http://strathprints.strath.ac.uk/id/eprint/38409

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