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The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the Physical Activity for Health Group based within the School of Psychological Sciences & Health. Research here seeks to better understand how and why physical activity improves health, gain a better understanding of the amount, intensity, and type of physical activity needed for health benefits, and evaluate the effect of interventions to promote physical activity.

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Lack of effect of proteinase-activated receptor 2 (PAR2) deletion on the pathophysiological changes produced by lipopolysaccharide in the mouse:comparison with dexamethasone

Kazerani, H. and Plevin, R.J. and Kawagoe, J. and Kanke, T. and Furman, B.L. (2004) Lack of effect of proteinase-activated receptor 2 (PAR2) deletion on the pathophysiological changes produced by lipopolysaccharide in the mouse:comparison with dexamethasone. Journal of Pharmacy and Pharmacology, 56 (8). pp. 1015-20. ISSN 0022-3573

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Abstract

Four pentacyclic tritepenes were isolated from Combretum imberbe Engl. & Diels, of which two are novel glycosidic derivatives of 1α,3β,23-trihydroxyolean-12-en-29-oic acid (hydroxyimberbic acid). Terminalia stuhlmannii Engl. & Diels stem bark yielded two glycosides of hydroxyimberbic acid, one of which is reported for the first time. The structures of the isolated compounds were elucidated by spectroscopic methods. Several of the compounds had antibacterial activity, imberbic acid showing particularly potent activity against Mycobacterium fortuitum and Staphylococcus aureus.