Strathprints logo
Strathprints Home | Open Access | Browse | Search | User area | Copyright | Help | Library Home | SUPrimo

Synthesis and neuromuscular blocking activity of 16beta-n-methylpiperazino steroidal derivatives

Jindal, D.P. and Piplani, P. and Fajrak, H. and Prior, C.B. and Marshall, I.G. (2002) Synthesis and neuromuscular blocking activity of 16beta-n-methylpiperazino steroidal derivatives. European Journal of Medicinal Chemistry, 37 (11). pp. 901-908. ISSN 0223-5234

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

Steroidal quaternary ammonium compounds 12 and 13 with quaternised nitrogen at positions 3 and 16 of the steroidal nucleus in androstane series were synthesised and their neuromuscular blocking activities and ganglion blocking activities were studied using chick biventer and anaesthetised cat as the models. The bisquaternary compounds 12 and 13 have been found to be greater in potency than d-tubocurarine. Acetoxy derivative 13 has been found to be more potent than pipecuronium bromide taking d-tubocurarine as the standard compound indicating the need of acetoxy function at position 16.

Item type: Article
ID code: 38396
Keywords: neuromuscular blocking activity, steroidal derivatives, Pharmacy and materia medica, Organic Chemistry, Drug Discovery, Pharmacology
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 12 Mar 2012 14:43
    Last modified: 04 Sep 2014 19:07
    URI: http://strathprints.strath.ac.uk/id/eprint/38396

    Actions (login required)

    View Item