Picture of a black hole

Strathclyde Open Access research that creates ripples...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of research papers by University of Strathclyde researchers, including by Strathclyde physicists involved in observing gravitational waves and black hole mergers as part of the Laser Interferometer Gravitational-Wave Observatory (LIGO) - but also other internationally significant research from the Department of Physics. Discover why Strathclyde's physics research is making ripples...

Strathprints also exposes world leading research from the Faculties of Science, Engineering, Humanities & Social Sciences, and from the Strathclyde Business School.

Discover more...

Synthesis and neuromuscular blocking activity of 16beta-n-methylpiperazino steroidal derivatives

Jindal, D.P. and Piplani, P. and Fajrak, H. and Prior, C.B. and Marshall, I.G. (2002) Synthesis and neuromuscular blocking activity of 16beta-n-methylpiperazino steroidal derivatives. European Journal of Medicinal Chemistry, 37 (11). pp. 901-908. ISSN 0223-5234

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

Steroidal quaternary ammonium compounds 12 and 13 with quaternised nitrogen at positions 3 and 16 of the steroidal nucleus in androstane series were synthesised and their neuromuscular blocking activities and ganglion blocking activities were studied using chick biventer and anaesthetised cat as the models. The bisquaternary compounds 12 and 13 have been found to be greater in potency than d-tubocurarine. Acetoxy derivative 13 has been found to be more potent than pipecuronium bromide taking d-tubocurarine as the standard compound indicating the need of acetoxy function at position 16.