Picture of virus under microscope

Research under the microscope...

The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

Explore SIPBS research

The changing structural chemistry of lithium anilide on solvation by pyridine, 4-methylpyridine or 4-tert-butylpyridine

Clegg, W and Horsburgh, L and Liddle, S T and Mackenzie, F M and Mulvey, Robert and Robertson, A (2000) The changing structural chemistry of lithium anilide on solvation by pyridine, 4-methylpyridine or 4-tert-butylpyridine. Journal of the Chemical Society, Dalton Transactions, 7. pp. 1225-1231. ISSN 0300-9246

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

A family of crystalline lithium anilide solvates, [{PhN(H)Li .(pyr)(2)}(2)] 1, [{PhN(H)Li .(4-Me-pyr)(2)}(2)] 2 and [{PhN(H)Li}(4).(4-Bu-t-pyr)(6)] 3 has been synthesised by reacting the aromatic primary amide with two molar equivalents of the appropriate pyridine-based solvent (pyridine, 4-methylpyridine and 4-tert-butylpyridine, respectively) in hexane-toluene solution. X-Ray crystallographic studies have revealed three contrasting structures: 1 adopts a dinuclear, dimeric [(anilido)N-Li](2) ring arrangement with a transoid (anti) conformation of amido substituents; 2 adopts a similar arrangement but with a cisoid (syn) conformation of amido substituents; and 3 adopts a novel tetranuclear arrangement with a central [(anilido)N-Li](2) transoid ring, separating two mixed ligand [(anilido)N-Li-(pyr)N-Li] rings, made possible by the unusual mu-bonding of a 4-tert-butylpyridine ligand. A combination of H-1, Li-7 and C-13 NMR spectroscopic studies at 300 K suggests similar environments exist for corresponding atoms in [H-2(8)]-toluene solutions of 1, 2 or 3. Further examination of the solution of 3 over the temperature window (300-193 K) has detected a fluxional structure involving the intramolecular exchange of two distinct types of anilido ligand, consistent with those present in the molecular structure of crystalline 3.