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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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Simultaneous SPR and electrochemical sensing of an alkane thiol self-assembled monolayer (SAM) - towards an optical biosensor

Sheridan, A.K. and Ngamukot, P. and Bartlett, P.N. and Wilkinson, J.S. (2004) Simultaneous SPR and electrochemical sensing of an alkane thiol self-assembled monolayer (SAM) - towards an optical biosensor. In: Second european workshop on optical fibre sensors. Proceedings of the Society of Photo-optical Instrumentation Engineers (SPIE), 5502 . SPIE, Bellingham, pp. 271-274. ISBN 0819454346

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Abstract

We present simultaneous electrochemical and waveguide surface plasmon resonance measurements demonstrating the electrochemically controlled desorption of a thiol monolayer from a gold electrode. Self-assembled thiol layers are used in biosensors to enable the attachment of lipids to the sensor. This work demonstrates the potential for development of the device for biological sensing applications. Simultaneous SPR electrochemical measurements are made during the thiol desorption and these results are discussed and compared to the results of a numerical simulation.