Gray, A. (2004) Self-assembly of cetyl linear polyethylenimine to give micelles, vesicles, and dense nanoparticles. Macromolecules, 37 (24). pp. 9114-9122. ISSN 0024-9297Full text not available in this repository. (Request a copy from the Strathclyde author)
The involvement of macromolecules in the formation of biological and other membranes has important implications for structural biology and nanoengineering. Using cetyl polyethylenimines of varying molecular weight and hydrophobicity, it was found that polymer hydrophobicity (mol % cetylation) controlled the nature of the self-assembly, giving micellar (cetyl groups < 23 mol %), vesicular (cetyl groups = 23−42 mol % or cetyl groups = 3−42 mol % with cholesterol), and dense nanoparticle (cetyl groups ≥ 49 mol %) aggregates. Thick (up to 15 nm) membranes due to the polyelectrolyte coating with the amphiphile were observed with low levels of cetylation only, and both dn/dc (indirectly) and vesicle/nanoparticle size (directly) varied linearly with mol % cetylation (r = 0.96−0.99).
|Keywords:||cetyl linear polyethylenimine , micelles, vesicles, nanoparticles, Pharmacy and materia medica, Materials Chemistry, Organic Chemistry, Polymers and Plastics, Inorganic Chemistry|
|Subjects:||Medicine > Pharmacy and materia medica|
|Department:||Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences|
|Depositing user:||Pure Administrator|
|Date Deposited:||29 Feb 2012 16:08|
|Last modified:||27 Apr 2016 12:38|