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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including those from the School of Psychological Sciences & Health - but also papers by researchers based within the Faculties of Science, Engineering, Humanities & Social Sciences, and from the Strathclyde Business School.

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Freezing and folding behavior in simple off-lattice heteropolymers

Magee, James E. and Warwicker, J. and Lue, L. (2004) Freezing and folding behavior in simple off-lattice heteropolymers. Journal of Chemical Physics, 120 (23). pp. 11285-11291. ISSN 0021-9606

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Abstract

We have performed parallel tempering Monte Carlo simulations using a simple continuum heteropolymer model for proteins. All 10 heteropolymer sequences which we have studied have shown first-order transitions at low temperature to ordered states dominated by single chain conformations. These results are in contrast with the theoretical predictions of the random energy model for heteropolymers, from which we would expect continuous transitions to glassy behavior at low temperatures.