Ederer, M. and Bullinger, Eric and Gilles, E.D. and Allgöwer, F. (2003) An approach for dividing models of biological reaction networks into functional units. Transactions of the Society for Modelling and Simulation International, 79 (12). pp. 703-716.Full text not available in this repository. (Request a copy from the Strathclyde author)
Biological reaction networks consist of many substances and reactions between them. Like many other biological systems, they have a modular structure. Therefore, a division of a biological reaction network into smaller units highly facilitates its investigation. The authors propose an algorithm to divide an ordinary differential equation (ODE) model of a biological reaction network hierarchically into functional units. For every compound, an activity function dependent on concentration or concentration change rate is defined. After performing suitable simulations, distances between the compounds are computed by comparing the activities along the trajectories of the simulation. The distance information is used to generate a dendrogram revealing the internal structure of the reaction network. The algorithm identifies functional units in two models of different networks: catabolite repression in Escherichia coli and epidermal growth factor (EGF) signal transduction in mammalian cells.
|Keywords:||biological reaction networks, simulation, catabolite repression, Electrical engineering. Electronics Nuclear engineering, Computer Graphics and Computer-Aided Design, Software, Modelling and Simulation, Computational Theory and Mathematics, Computer Science Applications|
|Subjects:||Technology > Electrical engineering. Electronics Nuclear engineering|
|Department:||Faculty of Engineering > Electronic and Electrical Engineering|
|Depositing user:||Pure Administrator|
|Date Deposited:||27 Feb 2012 15:05|
|Last modified:||22 Mar 2017 10:13|