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An approach for dividing models of biological reaction networks into functional units

Ederer, M. and Bullinger, Eric and Gilles, E.D. and Allgöwer, F. (2003) An approach for dividing models of biological reaction networks into functional units. Transactions of the Society for Modelling and Simulation International, 79 (12). pp. 703-716.

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Abstract

Biological reaction networks consist of many substances and reactions between them. Like many other biological systems, they have a modular structure. Therefore, a division of a biological reaction network into smaller units highly facilitates its investigation. The authors propose an algorithm to divide an ordinary differential equation (ODE) model of a biological reaction network hierarchically into functional units. For every compound, an activity function dependent on concentration or concentration change rate is defined. After performing suitable simulations, distances between the compounds are computed by comparing the activities along the trajectories of the simulation. The distance information is used to generate a dendrogram revealing the internal structure of the reaction network. The algorithm identifies functional units in two models of different networks: catabolite repression in Escherichia coli and epidermal growth factor (EGF) signal transduction in mammalian cells.

Item type: Article
ID code: 37945
Keywords: biological reaction networks, simulation, catabolite repression, Electrical engineering. Electronics Nuclear engineering, Computer Graphics and Computer-Aided Design, Software, Modelling and Simulation, Computational Theory and Mathematics, Computer Science Applications
Subjects: Technology > Electrical engineering. Electronics Nuclear engineering
Department: Faculty of Engineering > Electronic and Electrical Engineering
Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 27 Feb 2012 15:05
    Last modified: 04 Sep 2014 21:44
    URI: http://strathprints.strath.ac.uk/id/eprint/37945

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