Cairns, D. and Michalitsi, E. and Jenkins, T.C. and Mackay, S.P. (2002) Molecular modelling and cytotoxicity of substituted anthraquinonesas inhibitors of human telomerase. Bioorganic and Medicinal Chemistry Letters, 10. pp. 803-807. ISSN 0960-894X
Full text not available in this repository. (Request a copy from the Strathclyde author)Abstract
Molecular modelling has been carried out for a number of amine-functionalised anthraquinone derivatives to determine their extent of binding to G-tetraplex DNA and their ability to inhibit the enzymes telomerase and Taq polymerase. The results are compared to data obtained from a modified TRAP assay and show good correlation between the two methods. The findings suggest that anthraquinone derivatives of this type inhibit telomerase by stabilisation of four-stranded tetraplex structures associated with guanine-rich telomeric DNA regions.
| Item type: | Article |
|---|---|
| ID code: | 37878 |
| Keywords: | cytotoxicity , molecular modelling, human telomerase, Pharmacy and materia medica |
| Subjects: | Medicine > Pharmacy and materia medica |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
| Related URLs: | |
| Depositing user: | Pure Administrator |
| Date Deposited: | 24 Feb 2012 15:16 |
| Last modified: | 04 Oct 2012 12:27 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/37878 |
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