Zhang, L. and Parratt, J.R. and Beastall, G.H. and Pyne, N.J. and Furman, B.L. (2002) Streptozotocin diabetes protects against arrhythmias in rat isolated hearts: role of hypothyroidism. European Journal of Pharmacology, 435 (2-3). pp. 269-276. ISSN 0014-2999
Full text not available in this repository. (Request a copy from the Strathclyde author)Abstract
We examined the contribution of hypothyroidism to streptozotocin diabetes-induced alterations in the arrhythmia susceptibility of ex vivo hearts to regional zero-flow ischaemia. Diabetic rats received either protamine zinc insulin (10 IU/kg/day, s.c.) or triiodothyronine (10 microg/kg/day, s.c.) for 8 weeks commencing 72 h after injection of streptozotocin (60 mg/kg, i.p.). Arrhythmias were determined in ex vivo Langendorff-perfused hearts, subjected to a 30-min main left coronary artery occlusion, followed by 30-min reperfusion. Serum free thyroxine concentrations, rectal temperature and ex vivo heart rate were significantly decreased in the 8-week diabetic group.
| Item type: | Article |
|---|---|
| ID code: | 37849 |
| Keywords: | diabetes mellitus , insulin, triiodothyronine, hypothyroidism, ventricular fibrillation, body weight, blood glucose, Pharmacy and materia medica |
| Subjects: | Medicine > Pharmacy and materia medica |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Unknown Department Faculty of Science > Physiology & Pharmacology |
| Related URLs: | |
| Depositing user: | Pure Administrator |
| Date Deposited: | 23 Feb 2012 16:11 |
| Last modified: | 12 Mar 2012 11:48 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/37849 |
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