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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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The toxicity of troglitazone, roziglitazone and vitamin e in human hep g2 hepatoma cells

Ball, A.J. and Tettey, J.N.A. and Grant, M.H. (2004) The toxicity of troglitazone, roziglitazone and vitamin e in human hep g2 hepatoma cells. Toxicology, 194 (3). pp. 250-251. ISSN 0300-483X

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Abstract

Troglitazone (TGZ), a member of the thiazolidinedione class of drugs used to treat type-II diabetes, has been associated with hepatotoxicity (Biswas et al., 2001). TGZ differs structurally from the newer non-hepatotoxic glitazone, rosiglitazone (RGZ), in that it contains the chromanol moiety of Vitamin E (Vit E). This study compares the toxicity of TGZ, RGZ and Vit E in human HepG2 cells