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Modelling of macrophage gene expression in the interferon pathway

Yu, L. and Marshall, S. and Forster, T. and Ghazal, P. (2007) Modelling of macrophage gene expression in the interferon pathway. In: 2006 IEEE International Workshop on Genomic Signal Processing and Statstics, 2006-05-28 - 2006-05-30, Texas.

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Abstract

We propose a modeling approach based on Probabilistic Boolean Networks for the inference of genetic regulatory networks from gene expression time-course data in different biological conditions i.e. making use of the information contained in sets of genes and the interaction between genes rather than single-gene analyses. This model is a collection of traditional Probabilistic Boolean Networks. We also present an approach which is based on constrained prediction and Coefficient of Determination (COD) for the identification of the model from gene expression data. The modeling approach is applied in the context of pathway biology to the analysis of gene interaction networks.

Item type: Conference or Workshop Item (Paper)
ID code: 37700
Keywords: bioinformatics, biological system modeling , computational biology , gene expression , informatics , predictive models , macrophage , modelling, interferon pathway, Electrical engineering. Electronics Nuclear engineering
Subjects: Technology > Electrical engineering. Electronics Nuclear engineering
Department: Faculty of Engineering > Electronic and Electrical Engineering
Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 16 Feb 2012 14:13
    Last modified: 17 Jul 2013 15:25
    URI: http://strathprints.strath.ac.uk/id/eprint/37700

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