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In vivo generated Th1 cells can migrate to B cell follicles to support B cell responses

Brewer, James M. and Smith, Karen M. and Rush, Catherine M. and Riley, Jillian and Garside, Paul (2004) In vivo generated Th1 cells can migrate to B cell follicles to support B cell responses. Journal of Immunology, 173 (3). pp. 1640-1646. ISSN 0022-1767

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Abstract

The description of Th1 and Th2 T cell subsets rationalized the inverse correlation between humoral and cell-mediated immunity. Although Th1 cells were described to support cell-mediated immune responses, their role in supporting certain B cell responses was firmly established. However, there is now a prevailing preconception that provision of B cell help is entirely the domain of Th2 cells and that Th1 cells lack this capacity. Previous studies demonstrated that immunization using aluminum hydroxide adjuvants induces Ag-specific Th2 responses, whereas incorporation of IL-12 with aluminum hydroxide produces a Th1 inducing adjuvant. By immunizing TCR transgenic recipient mice in this fashion, we have generated Ag-specific, traceable Th1 and Th2 cells in vivo and assessed their follicular migration and ability to support B cell responses. In this study we have shown that in vivo polarized Th1 and Th2 cells clonally expand to similar levels and migrate into B cell follicles in which they support B cell responses to a similar degree. Critically, we present direct evidence that in vivo polarized, IFN- secreting Th1 cells migrate into B cell follicles where they can interact with Ag-specific B cells.

Item type: Article
ID code: 3766
Keywords: vivo generated, Th1 cells, migrate, B cell follicles, B cells, B cell responses, Immunology, Biology, Medicine(all)
Subjects: Science > Natural history > Biology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences > Centre for Biophotonics
Related URLs:
    Depositing user: Strathprints Administrator
    Date Deposited: 03 Jul 2007
    Last modified: 04 Sep 2014 12:46
    URI: http://strathprints.strath.ac.uk/id/eprint/3766

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