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The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including by researchers from the Department of Computer & Information Sciences involved in mathematically structured programming, similarity and metric search, computer security, software systems, combinatronics and digital health.

The Department also includes the iSchool Research Group, which performs leading research into socio-technical phenomena and topics such as information retrieval and information seeking behaviour.

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Performance of ultra-high-density microelectrode arrays

Gunning, D. E. and Chichilnisky, E. J. and Litke, A. M. and O'Shea, V. and Smith, K. M. and Mathieson, K. (2007) Performance of ultra-high-density microelectrode arrays. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 576 (1). pp. 215-219. ISSN 0168-9002

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Abstract

Imaging the electrical output activity of biological cells is important to gain an understanding of how cell networks process information. This has implications for the understanding of brain processing, such as that performed by the retina in encoding the visual scene. The performance and electrical quality of a state-of-the-art high-density 519-microelectrode array, that recorded simultaneously from hundreds of live retinal output cells (ganglion cells) is reported on. The fabrication process for these devices has been optimised and their electrical characteristics examined. The electrode arrays typically exhibit an impedance of 200 kO at 1 kHz and the RMS noise of the whole recording system is 7 mV with a signal to noise ratio of 20:1. With a view to direct stimulation of retinal ganglion cells, a low impedance Z ¼ 300 kO iridium oxide interface capable of delivering large currents Qcap ¼ 4 mC/cm2 to cells was also developed.