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Iontophoretic transdermal delivery of buspirone hydrochloride in hairless mouse skin

Meidan, V.M. (2003) Iontophoretic transdermal delivery of buspirone hydrochloride in hairless mouse skin. AAPS Journal, 264 (1-2). pp. 73-83. ISSN 1550-7416

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Abstract

The transdermal delivery of buspirone hydrochloride across hairless mouse skin and the combined effect of iontophoresis and terpene enhancers were evaluated in vitro using Franz diffusion cells. Iontophoretic delivery was optimized by evaluating the effect of drug concentration, current density, and pH of the vehicle solution. Increasing the current density from 0.05 to 0.1 mA/cm2 resulted in doubling of the iontophoretic flux of buspirone hydrochloride, while increasing drug concentration from 1% to 2% had no effect on flux. Using phosphate buffer to adjust the pH of the drug solution decreased the buspirone hydrochloride iontophoretic flux relative to water solutions. Incorporating buspirone hydrochloride into ethanol:water (50:50 vol/vol) based gel formulations using carboxymethylcellulose and hydroxypropylmethylcellulose had no effect on iontophoretic delivery. Incorporation of three terpene enhancers (menthol, cineole, and terpineol) into the gel and when combined with iontophoresis it was possible to deliver 10 mg/cm2/day of buspirone hydrochloride.

Item type: Article
ID code: 37217
Keywords: iontophoresis, transdermal , terpene, gel, buspirone hydrochloride, Pharmacy and materia medica, Pharmaceutical Science
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 31 Jan 2012 12:14
    Last modified: 04 Sep 2014 19:21
    URI: http://strathprints.strath.ac.uk/id/eprint/37217

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