Strathprints logo
Strathprints Home | Open Access | Browse | Search | User area | Copyright | Help | Library Home | SUPrimo

α2(VIII) collagen substrata enhance endothelial cell retention under acute shear stress flow via an α2β1 integrin dependent mechanism: an in vitro and in vivo study

Turner, Neill J. and Murphy, Michael O. and Kielty, Cay M. and Shuttleworth, Adrian and Black, Richard A. and Humphries, Martin J. and Walker, Michael G. and Canfield, Ann E. (2006) α2(VIII) collagen substrata enhance endothelial cell retention under acute shear stress flow via an α2β1 integrin dependent mechanism: an in vitro and in vivo study. Circulation, 114. pp. 820-829. ISSN 0009-7322

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

Essential to tissue-engineered vascular grafts is the formation of a functional endothelial monolayer capable of resisting the forces of blood flow. This study targeted {alpha}2(VIII) collagen, a major component of the subendothelial matrix, and examined the ability of and mechanisms by which endothelial cells attach to this collagen under static and dynamic conditions both in vitro and in vivo. These studies demonstrate that {alpha}2(VIII) collagen has the potential to improve both initial cell attachment and retention of endothelial cells on vascular grafts in vivo, which opens new avenues of research into the development of single-stage endothelialized prostheses and the next generation of tissue-engineered vascular grafts.

Item type: Article
ID code: 3721
Keywords: circulation, bioengineering, biomaterials, cells, vacular grafts, heart, Bioengineering, Physiology, Cardiology and Cardiovascular Medicine, Physiology (medical)
Subjects: Technology > Engineering (General). Civil engineering (General) > Bioengineering
Science > Physiology
Department: Faculty of Engineering > Bioengineering
Related URLs:
    Depositing user: Strathprints Administrator
    Date Deposited: 06 Jul 2007
    Last modified: 04 Sep 2014 13:46
    URI: http://strathprints.strath.ac.uk/id/eprint/3721

    Actions (login required)

    View Item