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Sensitivity analysis and experimental design of a stiff signal transduction pathway model

Yue, H. and Jia, J.F. and Brown, M. and Wang, H. and Kell, D.B. (2007) Sensitivity analysis and experimental design of a stiff signal transduction pathway model. In: 5th International Conference on Sensitivity Analysis of Model Output (SAMO2007), 2007-06-18, Budapest.

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Abstract

Sensitivity analysis is normally used to analyze how sensitive a system is with respect to the change of parameters or initial conditions and is perhaps best known in systems biology via the formalism of metabolic control analysis [1, 2]. The nuclear factor B (NF-B) signalling pathway is an important cellular signalling pathway, of which protein phosphorylation is a major factor controlling the activation of further downstream events. The NF-κB proteins regulate numerous genes that play important roles in inter- and intra-cellular signalling, cellular stress responses, cell growth, survival, and apoptosis. As such, its specificity and its role in the temporal control of gene expression are of crucial physiological interest.

Item type: Conference or Workshop Item (Paper)
ID code: 37111
Keywords: sensitivity analysis, signal transduction, Electrical engineering. Electronics Nuclear engineering
Subjects: Technology > Electrical engineering. Electronics Nuclear engineering
Department: Faculty of Engineering > Electronic and Electrical Engineering
Depositing user: Pure Administrator
Date Deposited: 26 Jan 2012 13:22
Last modified: 26 Mar 2015 18:58
URI: http://strathprints.strath.ac.uk/id/eprint/37111

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