Sensitivity analysis and experimental design of a stiff signal transduction pathway model
Yue, H. and Jia, J.F. and Brown, M. and Wang, H. and Kell, D.B. (2007) Sensitivity analysis and experimental design of a stiff signal transduction pathway model. In: 5th International Conference on Sensitivity Analysis of Model Output (SAMO2007), 2007-06-18.
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Abstract
Sensitivity analysis is normally used to analyze how sensitive a system is with respect to the change of parameters or initial conditions and is perhaps best known in systems biology via the formalism of metabolic control analysis [1, 2]. The nuclear factor B (NF-B) signalling pathway is an important cellular signalling pathway, of which protein phosphorylation is a major factor controlling the activation of further downstream events. The NF-κB proteins regulate numerous genes that play important roles in inter- and intra-cellular signalling, cellular stress responses, cell growth, survival, and apoptosis. As such, its specificity and its role in the temporal control of gene expression are of crucial physiological interest.
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Item type: Conference or Workshop Item(Paper) ID code: 37111 Dates: DateEvent2007PublishedSubjects: Technology > Electrical engineering. Electronics Nuclear engineering Department: Faculty of Engineering > Electronic and Electrical Engineering Depositing user: Pure Administrator Date deposited: 26 Jan 2012 13:22 Last modified: 09 Apr 2024 05:16 URI: https://strathprints.strath.ac.uk/id/eprint/37111